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Investigating how the SPT2 histone chaperone affects chromatin structure in human osteosarcoma cells.

ABSTRACT: Histone chaperones play essential roles in the regulation of chromatin structure. Here, we investigated how the SPT2 histone chaperone controls chromatin structure and accessibility in human cells (using U-2 OS osteosarcoma cells as model; these cells also express a H3.3-SNAP transgene). To achieve this, we performed ATAC-seq comparing WT U2OS vs three independent SPT2 KO clones (KO-3, KO-4 and KO-6

ORGANISM(S): Homo sapiens

PROVIDER: GSE243274 | GEO | 2023/09/15

REPOSITORIES: GEO

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