Transcriptomics

Dataset Information

0

Electro-assisted cell printing directs in vitro gastrulation and epiblast-like morphogenesis from human pluripotent stem cells


ABSTRACT: This study develop a versatile techonology to largely generate biomimetic epiblast-like tissues based on human induced pluripotent stem cells (hiPSCs) and well-defined biomatrix. Single hiPSCs are wrapped in laminin-alginate (L-A) hydrogel with optimized concentration and stably fabricated a large number of uniform hiPSCs-contained microspheres via electro-assisted bioprinting technology. It was observed that hiPSCs self-organized into disc-like cell clusters in L-A microspheres. Transition of microenvironment to L-A microspheres triggers the fate specification of disc-shaped tissues towards gastrulation with the identity resemble posterior epiblast population of human embryos around gastrulating stage, which is supported by transcriptome analysis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE243362 | GEO | 2024/08/01

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

| PRJNA1017888 | ENA
| 41280 | ecrin-mdr-crc
2024-01-20 | GSE253300 | GEO
2024-06-01 | GSE234907 | GEO
2024-10-16 | GSE276741 | GEO
2017-09-14 | GSE100599 | GEO
2024-09-21 | GSE277600 | GEO
| PRJEB79100 | ENA
2021-04-14 | PXD024150 | Pride
2016-03-20 | GSE61840 | GEO