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Accessible high-throughput single-cell whole genome sequencing with paired chromatin accessibility

ABSTRACT: We present a technique that leverages nucleosome disruption methodologies with the widely adopted 10x Genomics ATAC-seq library preparation workflow to produce scWGS profiles for copy number analysis in high throughput. We further demonstarte the ability to leverage indexed tagmentation using off-the-shelf reagents to perform scWGS multiplexing, or a co-assay that produces scWGS+ATAC data fromt he same cells, also witht he ability to multipelx samples.

ORGANISM(S): Homo sapiens

PROVIDER: GSE243430 | GEO | 2023/09/18

REPOSITORIES: GEO

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