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Double Negative T Cells Downregulate Intrahepatic Inflammation and Ameliorate Hepatic Ischemia and Reperfusion Injury via CD39-adenosinergic axis [ChIP-seq]

ABSTRACT: Converted double negative T cells (cDNT) highly expressed ATP hydrolytic enzyme CD39 and hydrolyzed extracellular ATP (eATP) into adenosine. We found that adenosine upregulated the transcription factor FOXO1 expression in cDNT. CUT&Tag assay was performed to investigate the FOXO1 binding promoter sites in cDNT.

ORGANISM(S): Mus musculus

PROVIDER: GSE246301 | GEO | 2025/01/29

REPOSITORIES: GEO

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Double Negative T Cells Downregulate Intrahepatic Inflammation and Ameliorate Hepatic Ischemia and Reperfusion Injury via CD39-adenosinergic axis [RNA-seq]

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