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Effects of Genistein on LNCaP Gene Expression

ABSTRACT: Gene expression profiling to identify genes significantly modulated by low and high doses of genistein in LNCaP cells. Significant genes were identified using StepMiner analysis and significantly altered pathways with Ingenuity Pathways analysis. Genistein significantly altered expression of transcripts involved in cell growth, carcinogen defenses and steroid signaling pathways. The effects of genistein on these pathways were confirmed by directly assessing dose-related effects on LNCaP cell growth, NQO-1 enzymatic activity and PSA protein expression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE24796 | GEO | 2010/10/20

SECONDARY ACCESSION(S): PRJNA132285

REPOSITORIES: GEO

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Effects of Genistein on LNCaP Gene Expression

Project description:Gene expression profiling to identify genes significantly modulated by low and high doses of genistein in LNCaP cells. Significant genes were identified using StepMiner analysis and significantly altered pathways with Ingenuity Pathways analysis. Genistein significantly altered expression of transcripts involved in cell growth, carcinogen defenses and steroid signaling pathways. The effects of genistein on these pathways were confirmed by directly assessing dose-related effects on LNCaP cell growth, NQO-1 enzymatic activity and PSA protein expression. A compound treatment design type is where the response to administration of a compound or chemical (including biological compounds such as hormones) is assayed.

2010-10-30 | E-GEOD-24796 | biostudies-arrayexpress

A quantitative proteomic based approach to study the genistein induced epigenetic reprogramming in MDA-MB231 cells

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Dietary Genistein Prevents Denervation-Induced Muscle Atrophy in Male Rodents via Effects on Estrogen Receptor-α.

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