Transcriptomics

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Defining the mechanism of systemic NK cell dysfunction associated with melanoma lung metastasis in spontaneous and experimental models


ABSTRACT: We isolated dysfunctional splenic NK cells in mice with melanoma metastasis and performed bulk RNA-seq with the NK cells to explore the mechanism of NK cell dysfunction with a special focus on signaling pathway linked to NK cell cytotoxicity.

ORGANISM(S): Mus musculus

PROVIDER: GSE248264 | GEO | 2024/08/27

REPOSITORIES: GEO

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