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Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE249392 | GEO | 2024/10/08

REPOSITORIES: GEO

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Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [TT-seq]

Project description:Exposure of unicellular or multicellular organisms to adverse environmental conditions, including nutrient deprivation, may induce a state of suspended animation or diapause. We here report that broad repression of RNA Pol II-driven gene expression by inhibiting the BET family's bromodomain-containing proteins (BET) triggers diapause in mouse embryonic stem (ES) cells. The diapause ES cells upregulate a functionally linked group of genes encoding negative regulators of MAP kinase signaling (NRMKS), which play a crucial role in ES cell differentiation. The elevated NRMKS expression is a hallmark of cells exposed to distinct diapause-inducing conditions, including mTOR inhibition, and are required for the pluripotency maintenance during diapause. Mechanistically, inhibition of mTORC1/2 leads to rapid decline of the Capicua transcriptional repressor (CIC) at the NRMKS gene promoters, followed by rapid transcriptional NRMKS gene upregulation. The mTOR and BET-dependent transcriptional switch supporting the undifferentiated state of the diapause ES cells suggests a broader usage of this mechanism in maintaining the undifferentiated state of metabolically dormant stem- or stem-like cells in different tissues.

2024-10-08 | GSE249391 | GEO

Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [RNA-seq]

2024-10-08 | GSE249389 | GEO

Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [PRO-seq]

2024-10-08 | GSE249388 | GEO

Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [ChIP-Seq]

2024-10-08 | GSE269920 | GEO

Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause

Project description:Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause

| PRJNA1048951 | ENA

Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [PRO-seq]

Project description:Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [PRO-seq]

| PRJNA1048960 | ENA

Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [RNA-seq]

Project description:Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [RNA-seq]

| PRJNA1048959 | ENA

Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [ChIP-Seq]

Project description:Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [ChIP-Seq]

| PRJNA1124121 | ENA

Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [TT-seq]

Project description:Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [TT-seq]

| PRJNA1048958 | ENA

MicroRNAs are differentially abundant during Aedes albopictus diapause maintenance but not diapause induction.

Project description:Diapause is a programmed dormancy that allows organisms to tolerate predictable periods of unfavourable conditions by temporarily halting development and reducing metabolism. Diapause is widespread amongst insects and is crucial for allowing organisms to coordinate their growth and reproduction with favourable environmental conditions. Although the adaptive significance of diapause is well understood, the molecular mechanisms underpinning diapause remain unresolved. We performed high-throughput sequencing to investigate the role of microRNAs (miRNAs) in the diapause of the Asian tiger mosquito, Aedes albopictus. We first investigated miRNAs in diapause induction by characterizing maternally provisioned miRNAs in mature oocytes of Ae. albopictus under diapause-inducing and diapause-averting conditions. Second, we investigated miRNAs in diapause maintenance by characterizing miRNAs in diapause and nondiapause pharate larvae. We identified 162 miRNAs, 152 previously known and 10 putatively novel. We identified no differentially abundant miRNAs in mature oocytes and seven differentially abundant miRNAs in pharate larvae. The predicted targets of differentially abundant miRNAs include genes affecting several processes related to diapause maintenance including ecdysone regulation, immune response, lipid metabolism and regulation of development. Our results suggest that Ae. albopictus does not maternally provision a unique set of miRNAs during diapause induction but miRNAs are a component of diapause maintenance in this species.

| S-EPMC5673581 | biostudies-literature

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