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Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [PRO-seq]

ABSTRACT: Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [PRO-seq]

PROVIDER: PRJNA1048960 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27104522_1.fastq.gz	Fastqsanger.gz
	SRR27104522_2.fastq.gz	Fastqsanger.gz
	SRR27104523_1.fastq.gz	Fastqsanger.gz
	SRR27104523_2.fastq.gz	Fastqsanger.gz
	SRR27104524_1.fastq.gz	Fastqsanger.gz

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Similar Datasets

Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [PRO-seq]

Project description:Exposure of unicellular or multicellular organisms to adverse environmental conditions, including nutrient deprivation, may induce a state of suspended animation or diapause. We here report that broad repression of RNA Pol II-driven gene expression by inhibiting the BET family's bromodomain-containing proteins (BET) triggers diapause in mouse embryonic stem (ES) cells. The diapause ES cells upregulate a functionally linked group of genes encoding negative regulators of MAP kinase signaling (NRMKS), which play a crucial role in ES cell differentiation. The elevated NRMKS expression is a hallmark of cells exposed to distinct diapause-inducing conditions, including mTOR inhibition, and are required for the pluripotency maintenance during diapause. Mechanistically, inhibition of mTORC1/2 leads to rapid decline of the Capicua transcriptional repressor (CIC) at the NRMKS gene promoters, followed by rapid transcriptional NRMKS gene upregulation. The mTOR and BET-dependent transcriptional switch supporting the undifferentiated state of the diapause ES cells suggests a broader usage of this mechanism in maintaining the undifferentiated state of metabolically dormant stem- or stem-like cells in different tissues.

2024-10-08 | GSE249388 | GEO

Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause

Project description:Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause

| PRJNA1048951 | ENA

Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [RNA-seq]

Project description:Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [RNA-seq]

| PRJNA1048959 | ENA

Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [ChIP-Seq]

Project description:Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [ChIP-Seq]

| PRJNA1124121 | ENA

Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [TT-seq]

Project description:Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [TT-seq]

| PRJNA1048958 | ENA

Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [TT-seq]

2024-10-08 | GSE249391 | GEO

Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [RNA-seq]

2024-10-08 | GSE249389 | GEO

Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [ChIP-Seq]

2024-10-08 | GSE269920 | GEO

Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-10-08 | GSE249392 | GEO

Next generation sequencing of Coccinella septempunctata L. with non-diapause, diapause, and diapause-terminated states

Project description:The most commonÂ ladybird beetle, Coccinella septempunctata L., is an excellent predator of crop pests such as aphids and white flies, and it shows a wide range of adaptability, a large appetite and a high reproductive ability. In this study, we collected female adults in three different states, i.e., non-diapause, diapause and diapause termination, for transcriptome sequencing. The experimental insects consisted of three different states as follows: Non-diapause female insects were reared at 24Â±1Â°C, with a RH of 70Â±10% and a 16:8 h light: dark (L: D) photoperiod and collected after their first oviposition. Female adults in diapause were reared at 18Â±1Â°C at an RH of 70Â±10% and a 10:14-h (L:D) photoperiod. The experimental diapause insects were collected after 30 days. Diapause-terminated adults were transferred to another climatic cabinet with the 30-day diapause insects and reared under the same conditions as the non-diapause insects. After their first oviposition, the female insects were collected and stored at -80Â°C. Three biological replicates per treatment (non-diapause, diapause, diapause-terminated) were sequenced using Illumina HiSeq 2500.

2016-06-01 | E-GEOD-75645 | biostudies-arrayexpress

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