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Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause

ABSTRACT: Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause

PROVIDER: PRJNA1048951 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27088866_1.fastq.gz	Fastqsanger.gz
	SRR27088866_2.fastq.gz	Fastqsanger.gz
	SRR27088867_1.fastq.gz	Fastqsanger.gz
	SRR27088867_2.fastq.gz	Fastqsanger.gz
	SRR27088868_1.fastq.gz	Fastqsanger.gz

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Similar Datasets

Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [PRO-seq]

Project description:Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [PRO-seq]

| PRJNA1048960 | ENA

Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [RNA-seq]

Project description:Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [RNA-seq]

| PRJNA1048959 | ENA

Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [ChIP-Seq]

Project description:Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [ChIP-Seq]

| PRJNA1124121 | ENA

Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [TT-seq]

Project description:Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [TT-seq]

| PRJNA1048958 | ENA

Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [TT-seq]

Project description:Exposure of unicellular or multicellular organisms to adverse environmental conditions, including nutrient deprivation, may induce a state of suspended animation or diapause. We here report that broad repression of RNA Pol II-driven gene expression by inhibiting the BET family's bromodomain-containing proteins (BET) triggers diapause in mouse embryonic stem (ES) cells. The diapause ES cells upregulate a functionally linked group of genes encoding negative regulators of MAP kinase signaling (NRMKS), which play a crucial role in ES cell differentiation. The elevated NRMKS expression is a hallmark of cells exposed to distinct diapause-inducing conditions, including mTOR inhibition, and are required for the pluripotency maintenance during diapause. Mechanistically, inhibition of mTORC1/2 leads to rapid decline of the Capicua transcriptional repressor (CIC) at the NRMKS gene promoters, followed by rapid transcriptional NRMKS gene upregulation. The mTOR and BET-dependent transcriptional switch supporting the undifferentiated state of the diapause ES cells suggests a broader usage of this mechanism in maintaining the undifferentiated state of metabolically dormant stem- or stem-like cells in different tissues.

2024-10-08 | GSE249391 | GEO

Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [RNA-seq]

2024-10-08 | GSE249389 | GEO

Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [PRO-seq]

2024-10-08 | GSE249388 | GEO

Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause [ChIP-Seq]

2024-10-08 | GSE269920 | GEO

Transcriptional shut-off of MAP kinase signaling enables pluripotency maintenance during diapause

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-10-08 | GSE249392 | GEO

Transcriptome profiling of Artemia cyst in in diapause stage and 5 hours after embryonic diapause termination

Project description:Embryonic diapause is a widely occurring evolutionary adaptation phenomenon in animals. Artemia is one of the classic animal models for diapause research. The current studies of Artemia diapause mainly focus on the induction and maintenance of the embryonic diapause, but there is little research on the molecular regulatory mechanism of Artemia embryonic diapause termination (EDT) and embryonic reactivation. Here the gene expression of Artemia cyst in diapause stage and 5 hours after embryonic diapause termination (EDT), which is in post-diapause stage were tested by RNA-seq to analyze the mechanism of signal regulation involved in Artemia EDT at the molecular level.

2024-05-01 | GSE249417 | GEO

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