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Effect of treatment by BAY1217389 for 48 hr on H1944

ABSTRACT: We reported that MPS-1 inhibitors activate cGAS-STING pathway in tumor cells by forming micronuclei and inducing cytokine secretion such as type I interferon, CCL5, and CXCL10, thereby promoting immune cell migration and inducing tumor cell shrinkage.　In the present study, we performed RNA -seq to search for negative regulators of STING pathway by forcibly activating it in H1944 cells with MPS-1 inhibitors, BAY1217389 and found that the administration of BAY1217389 for 48-hour treatment increased downstream factors of STING pathway and genes involved in antigen presentation, while we found elevation of negative regulators such as TREX1.

ORGANISM(S): Homo sapiens

PROVIDER: GSE252340 | GEO | 2024/05/08

REPOSITORIES: GEO

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