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Effects of Myotonic Dystrophy (DM1) models on hepatocyte transcriptomes

ABSTRACT: Myotonic Dystrophy (DM1), a common neuromuscular disease, has been shown to have detrimental effects on the livers of patients. To study whether DM1 is directly altering liver function or whether these effects are secondary to DM1 induced functional changes in other tissues, we sequenced the transcriptomes of hepatocytes from liver-specific and whole-body murine models of DM1. We found substantial transcriptomic alteration in the liver-specific model, along with distinguishable physiological changes in the livers of both the liver-specific and whole-body models. This data serves as a survey of transcriptomic alterations in occurring in the livers of DM1 patients.

ORGANISM(S): Mus musculus

PROVIDER: GSE252827 | GEO | 2024/09/26

REPOSITORIES: GEO

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Myotonic dystrophy type 1 (DM1) leads to altered mRNA expression in heart tissue

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