Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Role of neuroinflammation and skeletal muscle interaction in intermittent restraint stress

ABSTRACT: We propose that neuroinflammation and skeletal muscle interaction in intermittent restraint stress regulate skeletal muscle mass through a defined mechanism.

ORGANISM(S): Mus musculus

PROVIDER: GSE253451 | GEO | 2024/01/22

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Skeletal muscle response to high-intensity intermittent exercise training in young men

Project description:High-intensity intermittent exercise training (HIIT) has been proposed as an effective approach for improving both anaerobic and aerobic capacities. However, the molecular response of muscles to HIIT remains unknown. We used microarray to examine the effects of HIIT on global gene expression in human skeletal muscle.

2018-11-30 | GSE109657 | GEO

Skeletal Muscle TFEB Signaling Promotes Central Nervous System Function and Reduces Neuroinflammation during Aging and Neurodegenerative Disease

Project description:Skeletal muscle has recently arisen as a novel regulator of Central Nervous System (CNS) function and aging, secreting bioactive molecules known as myokines with metabolism-modifying functions in targeted tissues, including the CNS. Here we report the generation of a novel transgenic mouse with enhanced skeletal muscle lysosomal and mitochondrial function via targeted overexpression of Transcription Factor E-B (TFEB). We have discovered that the resulting geroprotective benefits in skeletal muscle reduces neuroinflammation and accumulation of tau-associated pathological hallmarks in a mouse model of tau pathology. Muscle TFEB overexpression also significantly ameliorates proteotoxicity, reduces neuroinflammation and promotes transcriptional remodeling of the aging CNS, preserving cognition and memory in aging mice. Our results implicate the maintenance of skeletal muscle function throughout aging to direct regulation of CNS health and disease, and suggest that skeletal-muscle originating factors may act as novel therapeutic targets against age-associated neurodegenerative disorders.

2023-12-06 | PXD045241 | panorama

Intermittent glucocorticoid treatment enhances skeletal muscle performance through sexually dimorphic mechanisms

Project description:Intermittent glucocorticoid treatment enhances skeletal muscle performance through sexually dimorphic mechanisms

| PRJNA778881 | ENA

RNA sequencing in healthy controls, intermittent claudicant, and CLI patient skeletal muscle

Project description:RNA sequencing in healthy controls, intermittent claudicant, and CLI patient skeletal muscle

| PRJNA493824 | ENA

Skeletal muscle response to high-intensity intermittent exercise training in young men

Project description:Skeletal muscle response to high-intensity intermittent exercise training in young men

| PRJNA431609 | ENA

RNA sequencing in healthy controls, intermittent claudicant, and CLI patient skeletal muscle

Project description:Gastrocnemius muscle biopsies were obtained from 15 health older adults without peripheral artery disease (PAD), 20 PAD patients with intermittent claudication, and 16 patients with critical limb ischemia undergoing limb amputation. Gene expression analysis was performed using RNA sequencing analysis.

2018-11-30 | GSE120642 | GEO

Intermittent glucocorticoid treatment enhances skeletal muscle performance through sexually dimorphic mechanisms [RNA-seq]

Project description:Intermittent glucocorticoid treatment enhances skeletal muscle performance through sexually dimorphic mechanisms [RNA-seq]

| PRJNA714668 | ENA

Intermittent glucocorticoid treatment enhances skeletal muscle performance through sexually dimorphic mechanisms [ChIP-seq]

Project description:Intermittent glucocorticoid treatment enhances skeletal muscle performance through sexually dimorphic mechanisms [ChIP-seq]

| PRJNA778225 | ENA

Expression data from rat soleus during chronic intermittent physical inactivity

Project description:Global gene expression of the rat soleus muscle was assessed with microarrays after 11 days of intermittent physical inactivity (10 hr/day) and compared to normally caged rats with voluntary standing and intermittent cage movements. Keywords: between group design

2006-07-04 | GSE5217 | GEO

Identification of therapeutic targets for treatment of intermittent claudication that mimic the effects of exercise

Project description:Exercise is considered as the most efficacious intervention for improving walking capacity in patients with intermittent claudication (IC). Despite its benefits, the underlying mechanisms inducing this effect remain unclear. To elucidate the local mechanisms in skeletal muscle, we previously developed an electrical stimulating (ES) model which caused skeletal muscle contraction mimicking exercise. ES showed the improvement in walking ability in rat IC model. In this study, we compared gene expressions among hindlimb ischemia (Isch) group, Isch + exercise group, and Isch + ES group in rat using GeneChip analysis and real-time PCR. By extracting genes which were similarly altered in both exercise and ES groups compared with Isch group, we revealed candidate genes that might be involved in improvement of walking ability.

2020-01-05 | GSE140629 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data