Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Role of neuroinflammation and skeletal muscle interaction in intermittent restraint stress

ABSTRACT: Role of neuroinflammation and skeletal muscle interaction in intermittent restraint stress

PROVIDER: PRJNA1065832 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR27589975_1.fastq.gz	Fastqsanger.gz
	SRR27589975_2.fastq.gz	Fastqsanger.gz
	SRR27589976_1.fastq.gz	Fastqsanger.gz
	SRR27589976_2.fastq.gz	Fastqsanger.gz
	SRR27589977_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Role of neuroinflammation and skeletal muscle interaction in intermittent restraint stress

Project description:We propose that neuroinflammation and skeletal muscle interaction in intermittent restraint stress regulate skeletal muscle mass through a defined mechanism.

2024-01-22 | GSE253451 | GEO

Skeletal muscle response to high-intensity intermittent exercise training in young men

Project description:High-intensity intermittent exercise training (HIIT) has been proposed as an effective approach for improving both anaerobic and aerobic capacities. However, the molecular response of muscles to HIIT remains unknown. We used microarray to examine the effects of HIIT on global gene expression in human skeletal muscle.

2018-11-30 | GSE109657 | GEO

Bcl6 controls meningeal Th17-B cell interaction in murine neuroinflammation

Project description:Bcl6 controls meningeal Th17-B cell interaction in murine neuroinflammation

| PRJNA737340 | ENA

Intermittent glucocorticoid treatment enhances skeletal muscle performance through sexually dimorphic mechanisms

Project description:Intermittent glucocorticoid treatment enhances skeletal muscle performance through sexually dimorphic mechanisms

| PRJNA778881 | ENA

Gene expression changes in LPS-induced neuroinflammation

Project description:Neuroinflammation plays a role in the progression of several neurodegenerative disorders. We used a lipolysaccharide (LPS) model of neuroinflammation to characterize the gene expression changes underlying the inflammatory and behavioral effects of neuroinflammation. A single intracerebroventricular injection of LPS (5 ug) was administered into the lateral ventricle of mice and, 24 hours later, we examined gene expression in the cerebral cortex and hippocampus using microarray technology. Gene Ontology (GO) terms for inflammation and the ribosome were significantly enriched by LPS, whereas GO terms associated with learning and memory had decreased expression. We detected 224 changed transcripts in the cerebral cortex and 170 in the hippocampus. Expression of Egr1 (also known as Zif268) and Arc, two genes associated with learning and memory, was significantly lower in the cortex, but not hippocampus, of LPS-treated animals. Overall, altered expression of these genes may underlie some of the inflammatory and behavioral effects of neuroinflammation. Mice were given intracerebroventricular injections of saline vehicle (n = 4) or lipopolysaccharide (n = 4). Twenty-four hours later, we dissected the hippocampus and cerebral cortex and processed the tissue for microarray analysis. Gene expression changes observed in the microaray data were validated with quantitative real-time PCR.

2008-11-01 | E-GEOD-12284 | biostudies-arrayexpress

Skeletal muscle response to high-intensity intermittent exercise training in young men

Project description:Skeletal muscle response to high-intensity intermittent exercise training in young men

| PRJNA431609 | ENA

RNA sequencing in healthy controls, intermittent claudicant, and CLI patient skeletal muscle

Project description:RNA sequencing in healthy controls, intermittent claudicant, and CLI patient skeletal muscle

| PRJNA493824 | ENA

Intermittent Hypoxia ageing

Project description:Expression data from mice exposed to intermittent hypoxia and mice reared for 12 months. We used microarrays to analyze the transcriptome of hippocampus from mice exposed to intermittent hypoxia or aged mice.

2016-12-27 | GSE62385 | GEO

Skeletal Muscle TFEB Signaling Promotes Central Nervous System Function and Reduces Neuroinflammation during Aging and Neurodegenerative Disease

Project description:Skeletal muscle has recently arisen as a novel regulator of Central Nervous System (CNS) function and aging, secreting bioactive molecules known as myokines with metabolism-modifying functions in targeted tissues, including the CNS. Here we report the generation of a novel transgenic mouse with enhanced skeletal muscle lysosomal and mitochondrial function via targeted overexpression of Transcription Factor E-B (TFEB). We have discovered that the resulting geroprotective benefits in skeletal muscle reduces neuroinflammation and accumulation of tau-associated pathological hallmarks in a mouse model of tau pathology. Muscle TFEB overexpression also significantly ameliorates proteotoxicity, reduces neuroinflammation and promotes transcriptional remodeling of the aging CNS, preserving cognition and memory in aging mice. Our results implicate the maintenance of skeletal muscle function throughout aging to direct regulation of CNS health and disease, and suggest that skeletal-muscle originating factors may act as novel therapeutic targets against age-associated neurodegenerative disorders.

2023-12-06 | PXD045241 | panorama

Intermittent glucocorticoid treatment enhances skeletal muscle performance through sexually dimorphic mechanisms [ChIP-seq]

Project description:Intermittent glucocorticoid treatment enhances skeletal muscle performance through sexually dimorphic mechanisms [ChIP-seq]

| PRJNA778225 | ENA