Transcriptomics

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Exchange of subtelomeric regions between chromosomes 4q and 10q: a novel way to revert the FSHD genotype and phenotype


ABSTRACT: In this study we used the CRISPR-Cas9 technique to induce the targeted 4q35;10q26 translocation in FSHD myoblasts. We were able to demonstrate that t(4;10)(q35;q26) can generate recombinant genotypes which revert the pathological phenotype of the FSHD cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE254310 | GEO | 2024/03/01

REPOSITORIES: GEO

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