Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effect of Ginsenoside Rb1 on inflammatory reaction and odontogenic differentiation of human dental pulp cell

ABSTRACT: Ginsenoside Rb1 (G-Rb1) has been reported to diminish inflammation associated with diseases. We investigated the effect of G-Rb1 on the inflammatory reactions and the odontogenic differentiation of human dental pulp cells (hDPCs). G-Rb1 affected the levels of TNF-α, IL-6, and IL-8, as these showed reduced levels with exposure to lipopolysaccharide (LPS). Additionally, less mRNA and protein expressions of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) were shown. G-Rb1 suppressed the LPS-induced increase of cell adhesion molecules and inflammatory cytokines, while also inhibiting PI3K/Akt, phosphorylation of NF-κB transcription factors, ERK and JNK of MAPK signaling in hDPCs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE255672 | GEO | 2024/02/18

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Myostain is involved in GINSENOSIDE-Rb1-mediated anti-obesity

Project description:Myostain is involved in GINSENOSIDE-Rb1-mediated anti-obesity

| PRJNA744173 | ENA

RNA-sequencing of DMSO or Ginsenoside Rb1-treated Rat BMSCs

Project description:RNA-sequencing of DMSO or Ginsenoside Rb1-treated Rat BMSCs

| PRJNA856660 | ENA

Effects of endogenous GDF11 on the odontogenic differentiation of dental pulp stem cells

Project description:Knockdown of endogenous GDF11 downregulated the odontogenic differentiation of human dental pulp stem cells (hDPSCs). We performed RNA-seq analysis on hDPSCs transfected with GDF11 small interfering RNA (siRNA) and control siRNA after 7 days of odontogenic induction, in order to investigate the underlying mechanisms of endogenous GDF11 regulating odontogenic differentiation in hDPSC.

2020-06-03 | GSE151435 | GEO

Expression data from odontogenic tumours

Project description:The aim of the study was to elucidate the cellular origin of ameloblastoma and keratocystic odontogenic tumour, neoplasms believed to arise from dental epithelial cells, by carrying out a genome-wide expression analysis.

2014-12-02 | GSE38494 | GEO

Wnt/β-catenin signaling, which is activated in odontomas, reduces Sema3A expression to regulate odontogenic epithelial cell proliferation and tooth germ development

Project description:Odontomas are classified as odontogenic benign tumors, which show disorganized dental mineralized hard tissue formation in the jaw, but mechanisms in the induction of odontomas remain to be clarified. Odontomas are also thought to be developmental anomalies of tooth germ, which frequently occur in patients with familial adenomatous polyposis (FAP) involving activation of Wnt/b-catenin signaling. However, the roles of Wnt/b-catenin signaling in odontomas or odontogenic cells remain to be clarified. The current study was conducted to investigate the expression of b-catenin in odontomas and the function of Wnt/b-catenin signaling in odontogenic epithelial cells and tooth germ development. b-catenin frequently accumulated in the nucleus and/or cellular cytoplasm of remaining odontogenic epithelial cells in human odontoma specimens, immunohistochemically. Activation of Wnt/b-catenin signaling inhibited odontogenic epithelial cell proliferation and mouse tooth germ development, while inducing epithelial bud formation in the novel developed epithelial tooth bud culture system derived from mouse tooth germ. We identified Semaphorin 3A (Sema3A) as a downstream molecule of Wnt/b-catenin signaling using DNA microarray analysis and showed that Wnt/b-catenin signaling-dependent reduction of Sema3A expression resulted in suppression of odontogenic epithelial cell proliferation. Novel developed epithelial tooth bud culture system revealed that Sema3A expression is required in epithelial budding morphogenesis. These results suggest that Wnt/b-catenin signaling negatively regulates odontogenic epithelial cell proliferation and tooth germ development through decreased-Sema3A expression, and aberrant activation of Wnt/b-catenin signaling may be associated with the formation of odontomas.

2019-03-20 | GSE116739 | GEO

Effects of Ginseng Berries Concentrate and Ginsenoside Re on gene expression profiles.

Project description:C2C12 myocytes were treated with Ginseng Berries Concentrate and Ginsenoside Re to identify gene expression changes.

2024-03-03 | GSE259316 | GEO

RNA-seq analyses of human ameloblastoma and odontogenic keratocyst

Project description:Ameloblastoma (AM) is a benign but locally invasive tumor with high recurrence rates. Invasive behavior of the odontogenic tumor results in destruction of the adjacent jawbone and formation of daughter cysts, hindering the complete elimination of cancer cells during surgery. To understand the underlying mechanism of AM invasion, we compared the transcriptome of AM with that of an odontogenic keratocyst (OKC), a dental epithelium-originated cyst with non-invasive characteristics.

2022-05-02 | GSE186489 | GEO

Expression data from odontogenic epithelial cells

Project description:The aim to the study was to elucidate the character of odontogenic epithelial cells from epithelial cell rests of Malassez in comparison with gingival epithelial cells by carrying out a geome-wide expression analysis.

2015-11-18 | GSE75085 | GEO

Remission for loss of odontogenic potential in a new micromilieu in vitro

Project description:During embryonic organogenesis, the odontogenic potential resides in dental mesenchyme from the bud stage until birth. Mouse dental mesenchymal cells (mDMCs) isolated from the inductive dental mesenchyme of developing molars are frequently used in the context of tooth development and regeneration. cultured mDMCs could retain the odontogenic potential for 24 h with a ratio of 60% for tooth formation, but mDMCs were incapable of supporting tooth formation after more than 24 h in culture. To reveal the underlying mechanism of the impairment of odontogenic potential, we generated gene expression profiles from mDMCs in culture using RNA-seq.

2016-10-31 | GSE78228 | GEO

A systematic exploration on Ginsenoside Rg5 reveals proresolving functions in airway mucous cells.

Project description:Ginsenoside Rg5 reveals proresolving functions in airway mucous cells through inhibition of ROS production and promoting anti-inflammation factors

2023-01-25 | GSE173990 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data