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Expression data from odontogenic tumours

ABSTRACT: The aim of the study was to elucidate the cellular origin of ameloblastoma and keratocystic odontogenic tumour, neoplasms believed to arise from dental epithelial cells, by carrying out a genome-wide expression analysis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE38494 | GEO | 2014/12/02

SECONDARY ACCESSION(S): PRJNA168020

REPOSITORIES: GEO

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RNA-seq analyses of human ameloblastoma and odontogenic keratocyst

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Project description:Knockdown of endogenous GDF11 downregulated the odontogenic differentiation of human dental pulp stem cells (hDPSCs). We performed RNA-seq analysis on hDPSCs transfected with GDF11 small interfering RNA (siRNA) and control siRNA after 7 days of odontogenic induction, in order to investigate the underlying mechanisms of endogenous GDF11 regulating odontogenic differentiation in hDPSC.

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Gene expression profile during odontogenic differentiation was analyzed using a microarray (miRNA).

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