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Inhibition of the mineralocorticoid Receptor reduces Cirrhosis associated changes of hepatocyte Glucose and Lipid Metabolism in hepatocytes

ABSTRACT: Background & aims: Recent studies have suggested that mineralocorticoid receptor (MR) activation may contribute to the progression of liver cirrhosis. Hypoxia, a common feature in liver cirrhosis, has been found to induce MR activation hepatocytes. However, the impact of non-physiological MR activation remains poorly understood. In this study, we investigate the effect of cirrhosis-induced MR activation in hepatocytes. Methods: RNA sequencing followed by gene ontology term enrichment analysis was performed on liver samples from rats treated for 12 weeks with or without CCl4 and for the last four weeks with or without eplerenone (MR antagonist). We investigated if these changes can be mimicked by hypoxia and if those changes lead to alterations of glucose and lipid metabolism in primary rat hepatocytes (pRH) and human HepG2 cells.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE255673 | GEO | 2024/12/27

REPOSITORIES: GEO

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