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Hi-C and Capture Hi-C maps in WT and Zfp661 knockout mESCs

ABSTRACT: In this assay, we aimed to investigate the impacts of ZFP661 on the permeability of CTCF barriers to chromatin interactions. To achieve this, we generated high-resolution Hi-C maps using WT and Zfp661 knockout (KO) mESCs. Our findings demonstrate that ZFP661 suppresses the trapping of cohesin at the CTCF barriers and modulates their permeability.

ORGANISM(S): Mus musculus

PROVIDER: GSE256450 | GEO | 2024/02/24

REPOSITORIES: GEO

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