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Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE25899 | GEO | 2011/01/14

SECONDARY ACCESSION(S): PRJNA135883

REPOSITORIES: GEO

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Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals.

Project description:Epigenetic information can be inherited through the mammalian germline and represents a plausible transgenerational carrier of environmental information. To test whether transgenerational inheritance of environmental information occurs in mammals, we carried out an expression profiling screen for genes in mice that responded to paternal diet. Offspring of males fed a low-protein diet exhibited elevated hepatic expression of many genes involved in lipid and cholesterol biosynthesis and decreased levels of cholesterol esters, relative to the offspring of males fed a control diet. Epigenomic profiling of offspring livers revealed numerous modest (?20%) changes in cytosine methylation depending on paternal diet, including reproducible changes in methylation over a likely enhancer for the key lipid regulator Ppara. These results, in conjunction with recent human epidemiological data, indicate that parental diet can affect cholesterol and lipid metabolism in offspring and define a model system to study environmental reprogramming of the heritable epigenome.

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Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals

Project description:This SuperSeries is composed of the following subset Series: GSE25895: Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (dye swap) GSE25896: Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (Affymetrix) GSE25897: Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (small RNA) GSE25898: Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (meDIP) Refer to individual Series

2011-01-14 | E-GEOD-25899 | biostudies-arrayexpress

Paternally induced transgenerational inheritance of susceptibility to diabetes in mammals

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (Affymetrix)

Project description:Epigenetic information can be inherited through the mammalian germline, and represents a plausible transgenerational carrier of environmental information. To test whether transgenerational inheritance of environmental information occurs in mammals, we carried out an expression profiling screen for genes in mice that responded to paternal diet. Characterising the change in RNA expression in sperm in response to different paternal diets. Examination of the effect of different diets, control diet, low-protein diet and caloric-restriction diet, on the RNA expression in the sperm. 8 samples: 3 are control diets and 2 are low protein diets 1 caloric restriction diet, and 2 samples from Epidydimal tissue.

2011-01-14 | E-GEOD-25896 | biostudies-arrayexpress

Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (meDIP)

Project description:Epigenetic information can be inherited through the mammalian germline, and represents a plausible transgenerational carrier of environmental information. To test whether transgenerational inheritance of environmental information occurs in mammals, we carried out an expression profiling screen for genes in mice that responded to paternal diet. As part of this analysis, we chracterise the changes in sperm cytosine methylation in response to different diets. Characterizing the RNA exression changes in livers of offspring mice in response to the paternal diet, comparing between low-protein diet and control-diet. Examination the effect of 3 different paternal diets, control diet, Caloric Restriction and low-protein diet, on sperm cytosine methylation.

2011-01-14 | E-GEOD-25898 | biostudies-arrayexpress

Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (dye swap)

Project description:Epigenetic information can be inherited through the mammalian germline, and represents a plausible transgenerational carrier of environmental information. To test whether transgenerational inheritance of environmental information occurs in mammals, we carried out an expression profiling screen for genes in mice that responded to paternal diet. Characterizing the RNA exression changes in livers of offspring mice in response to the paternal diet, comparing between low-protein diet and control-diet. Examination of the effect of 2 different paternal diets, control diet and low-protein diet, on the mRNA expression in the liver of the offsprinngs. 26 samples: including Control diet vs. Low-protein (with dye swap), and Control diet vs. Low-protein after fasting the mice.

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Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (small RNA)

Project description:Characterized the small (19-35 bp) RNA population from control and low protein offspring livers by high throughput sequencing. Eight sequencing lanes, one for each animal, with an average of 3.7 million mappable reads per lane. A number of miRNAs changed expression in the offspring from low protein diet fathers. Examination of the effect of 2 different paternal diets, control diet and low-protein diet, on the small RNA expression in the liver of the offsprings. 8 samples: 4 are control diets and 4 are low protein diets

2011-01-14 | E-GEOD-25897 | biostudies-arrayexpress

Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (meDIP)

Project description:Epigenetic information can be inherited through the mammalian germline, and represents a plausible transgenerational carrier of environmental information. To test whether transgenerational inheritance of environmental information occurs in mammals, we carried out an expression profiling screen for genes in mice that responded to paternal diet. As part of this analysis, we chracterise the changes in sperm cytosine methylation in response to different diets. Characterizing the RNA exression changes in livers of offspring mice in response to the paternal diet, comparing between low-protein diet and control-diet.

2011-01-14 | GSE25898 | GEO

Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (Affymetrix)

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Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (small RNA)

2011-01-14 | GSE25897 | GEO