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B cells in triple positive antiphospholipid syndrome

ABSTRACT: Peripheral B cell selection of autoreactive B cells is crucial for preventing autoimmunity. In this study, we identify that a significant proportion of antiphospholipid (aPL) B cells present in the naive compartment, exhibit polyreactivity and belong to the natural repertoire. We used scRNA Seq to follow B cells with aPL features throughout their development from naïve B cells to plasma cells in patients with PAPS.

ORGANISM(S): Homo sapiens

PROVIDER: GSE262240 | GEO | 2024/10/08

REPOSITORIES: GEO

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B cells in triple positive antiphospholipid syndrome

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