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Comprehensive analysis of circular RNA profiling in AZD9291-resistant non-small cell lung cancer cell lines

ABSTRACT: Considering the important role of circular RNAs (circRNAs) in cancers, we established AZD9291-resistant NSCLC cell lines (H1975/AZDR and HCC827/AZDR) and used microarray analysis to determine the circRNA expression profiles of the cells. The H1975/AZDR and HCC827/AZDR cell lines were induced by gradually increasing the drug concentration. CircRNA microarray expression profiles were obtained from H1975, HCC827, H1975/AZDR, and HCC827/AZDR cells and validated by quantitative reverse transcription PCR. Expression data were analyzed bioinformatically.

ORGANISM(S): Homo sapiens

PROVIDER: GSE263003 | GEO | 2024/04/05

REPOSITORIES: GEO

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