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The interplay between glucogenic amino acids and carbohydrate metabolisms in regulating the clinical fate of preterm infected newborns

ABSTRACT: Early-life sepsis remains one of the leading causes of global morbidity and mortality in the neonatal population, especially preterm infants. Using a preterm piglet model of neonatal sepsis to test nutritional interventions as a therapeutic approach, we demonstrated that high parenteral glucose induced hyperglycemia with severe sepsis, whereas glucose restriction offered protection against infection but led to severe hypoglycemia. Building on this, our current study aims to maintain normoglycemia through galactose metabolism or gluconeogenesis and reduce sepsis risks by substituting glucose with galactose, or supplementing glucogenic amino acids (GAAs).

ORGANISM(S): Sus scrofa

PROVIDER: GSE263512 | GEO | 2024/06/30

REPOSITORIES: GEO

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