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Aged skin exacerbates experimental osteoarthritis via enhanced IL-36R signaling

ABSTRACT: To investigate skin aging is an important driver of experimental osteoarthritis(OA) progression in mice via enhanced IL-36 receptor (IL-36R) signaling. we generated epidermis keratinocyte conditional knockout mice (IL-36Ra-cKO) with topical administration of capsid-mutant Adeno-associated virus 2 (AAV2) vector23 encoding Cre recombinase (AAV2-Cre) to IL-36Rafl/fl mice. Subsequently, epidermal skin tissues were collected from IL-36Rafl/fl and IL-36Ra-cKO mice for RNA sequencing analysis.

ORGANISM(S): Mus musculus

PROVIDER: GSE263907 | GEO | 2024/05/31

REPOSITORIES: GEO

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