Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single-cell RNA-seq of cardiac tissue from offsprings of dams with different fibre intake levels

ABSTRACT: We proposed that the maternal intake of fibre could influence the epigenetic conditions in the womb, consequently altering the cardiac characteristics of the offspring. Additionally, we speculated that maternal fibre intake might lead to significant changes in cardiac gene expression in the offspring by promoting the production of short-chain fatty acids (SCFAs). To examine the impact of maternal high fibre intake on the cellular composition of the heart, we conducted single-cell RNA sequencing (scRNA-seq) analysis on cardiac tissue from 6-week-old offspring who had not been subjected to any external challenges.

ORGANISM(S): Mus musculus

PROVIDER: GSE264691 | GEO | 2024/04/24

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Shared Molecules

Only show the datasets with similarity scores above: 0.5

Threshold

0.5

Similar Datasets

Butyrate, but not Propionate, Rescues Maternal Diet-Induced Neurocognitive Deficits in Offspring

Project description:Fiber diet plays a beneficial role in neurocognitive disorders, like dementia and Alzheimer’s Disease. However, insufficient fiber consumption in public increases the concern about public health, particularly about neurocognitive diseases. To survey the association between fiber dietary and neurocognitive performances, mice were subjected to normal-fiber diet or low-fiber diet during gestation, and the neurocognitive functions of the offspring were assessed. We found that maternal low-fiber diet impaired the cognitive functions, and the impairments can be reversed by butyrate, rather than propionate intake. Mechanism studies showed that HDAC4 might become the most potential mediator in butyrate-dependent neurocognitive improvement. Besides, using human maternal serum and paired umbilical cord blood samples, we demonstrated that the SCFA levels in offspring are positively correlated with levels in maternal serum. Those results provide a solid basis for not only maternal fiber diet regulates neurocognitive functions in offspring through altering SCFA levels, but clinical practice in SCFAs-dependent maternal intervention for offspring health.

2020-08-25 | GSE147022 | GEO

Cotton Fibre/Non Fibre

Project description:0dpa Fibre vs epidermal laser capture microdisection comparison Keywords: Development

2006-06-27 | GSE5133 | GEO

Cotton Fibre/Non Fibre

Project description:0dpa Fibre vs epidermal laser capture microdisection comparison Total RNA was isolated from each cell type (fibre initial or non-fibre epidermal pavement cell) from both Plant 1 and Plant 2. Hence, there were two biological replicates of each cell-type. Sub-samples of each cell type, designated here as technical replicates, were taken as separate batches of cells from different groups of ovules, but each from the same pair of plants. In particular, there were four sub-samples of fibre initial cells from plant 1 and two from plant 2 and two sub-samples of non-fibre epidermal from plant 1 and four from plant 2. The complete experiment involved three dye-swap pairs using a total of 6 arrays.

2006-06-26 | E-GEOD-5133 | biostudies-arrayexpress

Gene expression alternations in the offspring rat intestine from sitagliptin-treated dams

Project description:More and more evidence shows that maternal overnutrition may increase the risk of diabetes in offspring. This study aimed to find out whether maternal early sitagliptin intervention improves glucose intolerance through gut target in offspring.

2020-04-10 | GSE134070 | GEO

DNA methylation alternations in the offspring adipose from chromium restriction diet dams

Project description:Maternal chromium restriction may disturb susceptibility in offspring. Adipose from maternal chromium diet has 1214 CpG sites that exhibit differential DNA methylationregulated compared to control. We performed DNA methylation array analyses of offspring adipose from chromium restriction dams and control diet dams at 32 week (n=3 per group).

2016-09-08 | E-GEOD-82030 | biostudies-arrayexpress

DNA methylation alternations in the offspring hypothalamic tissue from inulin treatment dams

Project description:Maternal inulin treatment may moderate the metabolism in offspring. Hypothalamic tissue from maternal inulin treatment has CpG sites that exhibit differential DNA methylationregulated compared to maternal obesity.

2023-10-20 | GSE218748 | GEO

Sex specific gene expression differences in mouse pups from obese dams

Project description:Maternal obesity is increasingly common and negatively impact offspring health. Children born to mothers with obesity are at higher risk of developing diseases associated with abnormalities within the hematopoietic system such as atypical immune profiles, hematopoiesis, and metabolic diseases such as type 2 diabetes. Interestingly, disease risks are often dependent on the offspring’s sex, suggesting sex-specific reprogramming effect of maternal obesity on offspring hematopoietic stem and progenitor cell (HSPC) function. However, the impact of maternal obesity exposure on offspring HSPC function is largely unknown, and the capability of HSPC to regulate offspring metabolic health has not been studied. Here we examined differential transcriptomes of hematopoietic stem and progenitor cells from male and female pups (postnatal day 21) from dams given western diet or control diet. RNA-seq revealed inflammatory gene pathways in female MatOb offspring that potentially protect HSPC function.

2025-01-29 | GSE253870 | GEO

DNA methylation alternations in the offspring pancreatic tissue from hyperglycemic dams

Project description:Maternal hyperglycemia may disturb susceptibility in offspring. Pancreatic tissue from maternal hyperglycemia has CpG sites that exhibit differential DNA methylationregulated compared to control.

2023-10-13 | GSE218747 | GEO

DNA methylation alternations in the offspring liver from chromium restriction diet dams

Project description:Maternal chromium restriction may disturb susceptibility in offspring. Adipose from maternal chromium diet has 935 genes that exhibit differential DNA methylationregulated compared to control.

2019-05-30 | GSE82029 | GEO

MiRNA expression alternations in the offspring liver from chromium restriction diet dams

Project description:Maternal chromium restriction may disturb susceptibility in offspring. Liver from maternal chromium diet has 8 up- and 6 down- regulated miRNAs, compared to control.

2019-05-30 | GSE82026 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data