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Single-cell RNA-seq of cardiac tissue from offsprings of dams with different fibre intake levels

ABSTRACT: We proposed that the maternal intake of fibre could influence the epigenetic conditions in the womb, consequently altering the cardiac characteristics of the offspring. Additionally, we speculated that maternal fibre intake might lead to significant changes in cardiac gene expression in the offspring by promoting the production of short-chain fatty acids (SCFAs). To examine the impact of maternal high fibre intake on the cellular composition of the heart, we conducted single-cell RNA sequencing (scRNA-seq) analysis on cardiac tissue from 6-week-old offspring who had not been subjected to any external challenges.

ORGANISM(S): Mus musculus

PROVIDER: GSE264691 | GEO | 2024/04/24

REPOSITORIES: GEO

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