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Transcriptomic analysis of human vascular endothelial cell line (EA.hy926) exposed to okadaic acid

ABSTRACT: As the climate changes due to global warming, the frequency of appearance of marine-derived toxins increases. In particular, the need to investigate marine-derived toxins for which toxicity has not yet been identified is emerging. Blood vessels are passageways through which compounds entering the body move to various organs and are the sites first exposed to compounds. Therefore, it is important to know the effects of compounds on blood vessels when they enter the body. In this study, the human vascular endothelial cell line EA.hy926 was exposed to the marine toxins OA (IC20; 42.9 nM) and the mechanism of toxicity was investigated at the transcriptome level. Quantseq 3' mRNA sequencing was performed by extracting RNA from EA.hy926 cells exposed to the toxins. Differentially expressed genes were determined based on fold change ≥ 1.5 and P value < 0.05.

ORGANISM(S): Homo sapiens

PROVIDER: GSE267374 | GEO | 2024/05/18

REPOSITORIES: GEO

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Transcriptomic analysis of human vascular endothelial cell line (EA.hy926) exposed to okadaic acid

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