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RNA sequencing of antigen specific CD4+ T cells induced by high vs low doses of MHC-II restricted neoantigens

ABSTRACT: RNA sequencing of antigen specific CD4+ T cells induced by high vs low doses of MHC-II restricted neoantigens

PROVIDER: PRJNA1116134 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29162455_1.fastq.gz	Fastqsanger.gz
	SRR29162455_2.fastq.gz	Fastqsanger.gz
	SRR29162456_1.fastq.gz	Fastqsanger.gz
	SRR29162456_2.fastq.gz	Fastqsanger.gz
	SRR29162457_1.fastq.gz	Fastqsanger.gz

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Single-cell RNA sequencing of antigen specific CD4+ T cells induced by high vs low doses of MHC-II restricted neoantigens

Project description:Here, we report the impact of the dose of the MHC-II restricted neoantigens on the phenotypic and the effector function of tumor-specific CD4 T cells. Whereas vaccines containing low doses of MHC-II-restricted neoantigen (LDVax) generated helper CD4 T cells that promote the proliferation and the cytotoxic functions of CD8 T cells, vaccines containing high doses of MHC-II restricted neoantigen (HDVax) elicited type 1 regulatory T cells that suppress the antitumor immunity.

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Single-cell RNA sequencing of antigen specific CD4+ T cells induced by high vs low doses of MHC-II restricted neoantigens

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