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Epigenetic programming by trithorax supports the translation capacity of Drosophila memory neurons [RNA-seq Set1 & trr]

ABSTRACT: We have analyzed changes in histone H3 lysine 4 methylation (H3K4me) and gene expression resulting from trx knockdown (KD) in adult mushroom body neurons of Drosophila melanogaster.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE268425 | GEO | 2024/12/17

REPOSITORIES: GEO

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Similar Datasets

Epigenetic programming by trithorax supports the translation capacity of Drosophila memory neurons [ChIP-seq]

Project description:We have analyzed changes in histone H3 lysine 4 methylation (H3K4me) and gene expression resulting from trx knockdown (KD) in adult mushroom body neurons of Drosophila melanogaster.

2024-12-17 | GSE239492 | GEO

Epigenetic programming by trithorax supports the translation capacity of Drosophila memory neurons [RNA-seq trx]

2024-12-17 | GSE239491 | GEO

Epigenetic programming by trithorax supports the translation capacity of Drosophila memory neurons [RNA-seq trx]

Project description:Epigenetic programming by trithorax supports the translation capacity of Drosophila memory neurons [RNA-seq trx]

| PRJNA999448 | ENA

Epigenetic programming by trithorax supports the translation capacity of Drosophila memory neurons.

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-12-17 | GSE239493 | GEO

Distinct roles for COMPASS core subunits Set1, Trx, and Trr in the epigenetic regulation of Drosophila heart development

Project description:This study investigated the role Complex of Proteins Associated with Set1 (COMPASS) in heart development. These are evolutionarily highly conserved multiprotein complexes required for H3K4 methylation. In Drosophila, their core subunits are Set1, Trx, and Trr. We studied flies deficient for either of these three subunits their hearts. These flies showed high lethality at eclosion (emergence of adult flies from their pupal case) and significantly shortened lifespans for the adults that did emerge. Furthermore, their hearts showed reduced H3K4 monomethylation (H3K4me1) and dimethylation (H3K4me2), and significantly altered gene expression patterns. The data revealed that each of the COMPASS core subunits (Set1, Trx, and Trr) control methylation of different sets of genes with distinct temporal activity: Set1 throughout, whereas Trr was active early and Trx at later stages of heart development. We found that many metabolic pathways were active early in development and throughout, while muscle and heart differentiation processes were methylated during later stages of development. Taken together, the findings demonstrate the importance of COMPASS complexes during heart development, therewith supporting their implication in congenital heart diseases.

2024-01-03 | GSE240313 | GEO

Epigenetic programming by trithorax supports the translation capacity of Drosophila memory neurons.

Project description:Epigenetic programming by trithorax supports the translation capacity of Drosophila memory neurons.

| PRJNA999446 | ENA

Chromosomal clustering of genes in trithorax (trx) mutant larvae

2008-09-26 | GSE8748 | GEO

Chromosomal clustering of genes in trithorax (trx) mutant larvae

Project description:We have performed a systematic examination of genome-wide expression profiles using microarrays to reconstruct a global picture of the trx regulatory gene network in D. melanogaster. Using computational analysis of the microarray data, we have identified 25 clusters of genes potentially regulated by trx, most of them being located in the arm L of chromosome 3. Functional analysis revealed that most clusters are enriched in structural proteins involved in cuticle formation, which are preferently expressed in salivary glands. The same organization in clusters was observed in the transcriptomes of four independent experiments, being a distinctive feature of the regulatory networks of trx and other chromatin regulators (ASH2, NURF, Pc, ASH1). We have also identified many of these clusters in D. simulans, D. yakuba, D. pseudoobscura and partially in A. gambiae. Keywords: loss of function analysis Total RNA from w1118;+;+ larvae was pooled and used as a common reference in four microarrays against w1118;+;trxE3/trxB11 total RNA coming from two different extractions to take biological differences into account. Two amplifications from w1118;+;+ and one from each w1118;+;trxE3/trxB11 replicate were performed with the Amino-Allyl Messageamp II aRNA Amplification Kit (Ambion, Inc) to obtain amplified RNA (aRNA). The two arrays from each replicate pair were hybridized with the same amplified RNA from sample and common reference but with dyes (Cy3 and Cy5 from Amersham, Inc) swapped to take dye-bias into account.

2010-06-25 | E-GEOD-8748 | biostudies-arrayexpress

Epigenetic programming by trithorax supports the translation capacity of Drosophila memory neurons [ChIP-seq]

Project description:Epigenetic programming by trithorax supports the translation capacity of Drosophila memory neurons [ChIP-seq]

| PRJNA999449 | ENA

Distinct Roles for COMPASS Core Subunits Set1, Trx, and Trr in the Epigenetic Regulation of <i>Drosophila</i> Heart Development.

Project description:Highly evolutionarily conserved multiprotein complexes termed Complex of Proteins Associated with Set1 (COMPASS) are required for histone 3 lysine 4 (H3K4) methylation. Drosophila Set1, Trx, and Trr form the core subunits of these complexes. We show that flies deficient in any of these three subunits demonstrated high lethality at eclosion (emergence of adult flies from their pupal cases) and significantly shortened lifespans for the adults that did emerge. Silencing Set1, trx, or trr in the heart led to a reduction in H3K4 monomethylation (H3K4me1) and dimethylation (H3K4me2), reflecting their distinct roles in H3K4 methylation. Furthermore, we studied the gene expression patterns regulated by Set1, Trx, and Trr. Each of the COMPASS core subunits controls the methylation of different sets of genes, with many metabolic pathways active early in development and throughout, while muscle and heart differentiation processes were methylated during later stages of development. Taken together, our findings demonstrate the roles of COMPASS series complex core subunits Set1, Trx, and Trr in regulating histone methylation during heart development and, given their implication in congenital heart diseases, inform research on heart disease.

| S-EPMC10744143 | biostudies-literature

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