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Mettl3 deficiency in epidermal keratinocytes exacerbates psoriasis-like inflammation [MeRIPseq_mice]

ABSTRACT: We analyzed epidermal samples from keratinocyte-specific knockout Mettl3 (K14CreERT2;Mettl3fl/fl) mice and their controls (Mettl3fl/fl) in imiquimod-induced psoriasis-like skin lesions. Briefly, we established an imiquimod-induced psoriasis model in K14CreERT2;Mettl3fl/fl mice and their controls after tamoxifen injection, and epidermal samples were separated and collected from the skin lesions of the mice after 3 or 6 days of modeling (n=3 per group). The aim of this study was to investigate the mechanism by which Mettl3-mediated epidermal m6A methylation affects skin inflammation.

ORGANISM(S): Mus musculus

PROVIDER: GSE268745 | GEO | 2024/08/20

REPOSITORIES: GEO

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