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A novel mouse model of Prader-Willi Syndrome including the deletion of both Necdin and Magel2 genes

ABSTRACT: Prader-Willi syndrome (PWS) is a multigenic disorder caused by the loss of seven contiguous paternally expressed genes. Mouse models with inactivation of all PWS genes display 100% lethality within the first postnatal week and have not helped understand the postnatal pathophysiology of this syndrome. Knockout (KO) models for each candidate gene were also generated, but they lack the functional interactions and possible compensatory functions between PWS-related genes. Here, we generated a novel double KO mouse model to explore the effect of a combined deletion of Magel2 and Necdin.

ORGANISM(S): Mus musculus

PROVIDER: GSE269225 | GEO | 2024/12/02

REPOSITORIES: GEO

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A novel mouse model of Prader-Willi Syndrome including the deletion of both Necdin and Magel2 genes

Project description:A novel mouse model of Prader-Willi Syndrome including the deletion of both Necdin and Magel2 genes

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