Postnatal Allergic Inhalation Induces Glial Inflammation in the Olfactory Bulb and Leads to Autism-Like Traits in Mice

ABSTRACT: Autism spectrum disorder (ASD) is one of the most prevalent neurodevelopmental disorders. To clarify its detailed pathophysiology, we studied the association between neonatal allergic exposure and behavioral changes. Adult female C57BL/6J mice were immunized with adjuvant (alum) or ovalbumin emulsified by adjuvant. After immunization, mice were mated, and offspring were born in full-term. Postnatal mother and infant were simultaneously inhaled with allergen. After weaning, behavioral testing and histopathological analysis were conducted for male offspring. As a result, ovalbumin-inhaled allergic offspring showed decreased sociability and increased repetitive behavior, so-called ASD-like phenotype in mice. Histopathological analysis revealed that allergic mice showed increase of astroglia, microglia, and eosinophilic infiltration in the olfactory bulb, as well as increase of eosinophils in the nasal mucosa. Allergic mice also showed decrease of dendritic spine density and proportion of mature spines, suggesting the impairment of stimuli-induced synaptogenesis. In conclusion, postnatal allergic exposure induces autistic phenotype as well as allergic rhinitis, followed by glial inflammation in the olfactory bulb parenchyma.

ORGANISM(S): Mus musculus

PROVIDER: GSE271274 | GEO | 2024/07/06

REPOSITORIES: GEO