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Regulation of adipocyte de-differentiation and subsequent re-differentiation

ABSTRACT: We show the presence of de-differentiated fat (DFAT) cells in subcutaneous and visceral adipose depots under different dietary intervention conditions, whose transcriptomes resemble adipocytes with high differentiation potential and late-stage adipose stem and progenitor cells (ASPC). These data uncover the potential of adipocytes to undergo de-differentiation under regular physiological conditions and shed light on its role in life style change-induced weight loss and regain.

ORGANISM(S): Mus musculus

PROVIDER: GSE272938 | GEO | 2025/03/05

REPOSITORIES: GEO

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