Effect of Ndrg3-deficiency on gene expression by CD8SP thymocytes
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ABSTRACT: The objective of this study was to determine gene expression changes that occur as a result of Ndrg3-deficiency in mature CD8+ thymocytes. Our research has revealed that conditional ablation of Ndrg3 in the T cell lineage causes a significant loss of naive CD8+ T cells, and in order to determine the basis for this defect, we isolated mature, CD8 single-positive thymocytes from control and knockout mice, and subjected them to RNA-seq analysis to identify genes that were dysregulated in the absence of Ndrg3.
ORGANISM(S): Mus musculus
PROVIDER: GSE274174 | GEO | 2024/08/26
REPOSITORIES: GEO
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