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Multi-omic analysis of dendritic cell populations in the female genital tract.

ABSTRACT: The female genital tract (FGT) represents a complex and dynamic environment with specialized immune mechanisms uniquely designed to maintain a delicate balance between protection against invading pathogens and accommodating the unique physiological changes associated with reproductive function. Dendritic cells (DCs) are critical in shaping mucosal immunity against pathogens and maintaining tissue homeostasis. The unique ability of DCs to recognize invading pathogens through pattern recognition receptors (PRRs), and prime naive T cell function, make DCs ideal targets for vaccination and therapeutic strategies against cancers and infections. DC subsets and mononuclear phagocyte populations at human mucosal surfaces remain poorly defined. Local characterization of these populations is important, since DCs and mononuclear phagocyte populations are highly specialized depending on the tissue of residence.

ORGANISM(S): Homo sapiens

PROVIDER: GSE279774 | GEO | 2024/11/08

REPOSITORIES: GEO

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