Transcriptomics

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CMyb and vMyb in MCF7 cells


ABSTRACT: The transcriptional activities of c-Myb and its oncogenic variant v-Myb were compared by expressing them in human MCF7 cells using recombinant adenovirus vectors. A hybrid construct, 3Mutc, which is a variant of c-Myb harboring three v-Myb-derived DNA binding domain mutations was also analyzed. All the samples were compared to cells infected with a control adenovirus. The results showed that v-Myb, which differs from c-Myb only by N- and C-terminal deletions and eleven amino acid substitutions, has a qualitatively different transcriptional activity. Keywords: repeat

ORGANISM(S): Homo sapiens

PROVIDER: GSE2815 | GEO | 2005/06/14

SECONDARY ACCESSION(S): PRJNA92417

REPOSITORIES: GEO

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