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To examine the influence of the early stress of maternal separation on the hippocampal transcriptome in middle-aged life

ABSTRACT: In this study, we examined the consequences of the early stress (ES) of maternal separation on hippocampal gene expression in middle-aged animals. Middle-aged (15 months old) ES animals exhibit hippocampal transcriptome changes with a significant regulation of genes associated with ion binding, transcriptional regulation, cellular projection, cellular stress responsive pathways, neuronal development and chromatin remodeling.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE29414 | GEO | 2013/10/11

SECONDARY ACCESSION(S): PRJNA153991

REPOSITORIES: GEO

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To examine the influence of the early stress of maternal separation on the hippocampal transcriptome in middle-aged life

Project description:In this study, we examined the consequences of the early stress (ES) of maternal separation on hippocampal gene expression in middle-aged animals. Middle-aged (15 months old) ES animals exhibit hippocampal transcriptome changes with a significant regulation of genes associated with ion binding, transcriptional regulation, cellular projection, cellular stress responsive pathways, neuronal development and chromatin remodeling. Agilent one-color experiment, Agilent-024724 Genotypic-designed Custom Rattus Norvegicus 8x15k; Organism: Rattus norvegicus; Labeling kit: Agilent Quick-Amp labeling Kit (p/n5190-0442); Biological replicates: 5 per early stress group, 3 per control group

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