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Cellular aging can be monitored by DNA-methylation changes at specific CpG sites

ABSTRACT: Long-term culture associated changes need to be considered for quality control of cell preparations – especially in cellular therapy. Here we describe a simple method to track cellular aging based on continuous DNA-methylation changes at six specific CpG sites. This epigenetic signature can be used as a biomarker for various cell types to predict the state of cellular aging with regard to the number of passages or days of in vitro culture.

ORGANISM(S): Homo sapiens

PROVIDER: GSE29661 | GEO | 2012/05/22

SECONDARY ACCESSION(S): PRJNA141137

REPOSITORIES: GEO

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Cellular aging can be monitored by DNA-methylation changes at specific CpG sites

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