The role of HIF in FH-associated renal neoplasia
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ABSTRACT: Fumarate hydratase (FH) mutations predispose to renal cysts cancer. These cancers overexpress hypoxia-inducible factor-alpha (Hif-1a). We have generated a conditional Fh1 (mouse FH) knockout mice that develop renal cysts and overexpress Hif-1a. In order to identify the contribution of Hif-1a to cyst formation we have intercrossed our mice with conditional HIf-1a KO mice.
ORGANISM(S): Mus musculus
PROVIDER: GSE29988 | GEO | 2011/10/24
SECONDARY ACCESSION(S): PRJNA140707
REPOSITORIES: GEO
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