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An integrated transcriptome analysis to the characterization of host responses against infectious laryngostracheitis virus vaccine infection in chicken embryo lung cells

ABSTRACT: Host gene expression of chicken embryo lung cells infected an infectious laryngotracheitis virus (ILTV) vaccine strain comparing control uninfected lung cells. Goal was to identify the changes of host gene expression by ILTV vaccine infection.

ORGANISM(S): Gallus gallus

PROVIDER: GSE30269 | GEO | 2011/06/29

SECONDARY ACCESSION(S): PRJNA143731

REPOSITORIES: GEO

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An integrated transcriptome analysis to the characterization of host responses against infectious laryngostracheitis virus vaccine infection in chicken embryo lung cells

Project description:Host gene expression of chicken embryo lung cells infected an infectious laryngotracheitis virus (ILTV) vaccine strain comparing control uninfected lung cells. Goal was to identify the changes of host gene expression by ILTV vaccine infection. Two-condition experiment, uninfected chicken embryo lung cells vs. vaccine infected chicken embryo lung cells. Biological replicates: 1 control uninfected sample, 1 vaccinal ILTV infected experimental sample at each 1, 2, 3 and 4 dpi.

2011-06-29 | E-GEOD-30269 | biostudies-arrayexpress

Transcriptional Profiling of Host Gene Expression in Chicken Embryo Lung Cells Infected with Laryngotracheitis Virus

2010-03-11 | GSE20630 | GEO

Transcriptional Profiling of Host Gene Expression in Chicken Embryo Lung Cells Infected with Laryngotracheitis Virus

Project description:Transcriptional profiling of chicken embryo lung cells infected infectious laryngotracheitis virus (ILTV) comparing control uninfected lung cells. Goal was to determine the changes of host gene expression by ILTV infection and host-virus interaction. Two-condition experiment, uninfected chicken embryo lung cells vs. infected chicken embryo lung cells. Biological replicates: 1 control uninfected sample, 1 infected experimental sample at each 1dpi, 3dpi, 5dpi, and 7 dpi.

2010-03-10 | E-GEOD-20630 | biostudies-arrayexpress

Development of gene expression signatures for chicken LMH cells infected with infectious laryngotracheitis virus (ILTV)

2015-10-24 | GSE70855 | GEO

Transcriptome analysis reveals an activation of MHC-I and MHC-II pathways in chicken trachea immunized with infectious laryngotracheitis virus vaccine

Project description:Infectious laryngotracheitis (ILT) is an acute, contagious, upper respiratory disease, which is caused by gallid herpesvirus 1 (GaHV-1). Due to the mortality rates up to 70% depending on the virulence of the virus, it is of economic importance of the disease to explore the etiology of the ILT in the poultry industry. In this study, 15-day-old SPF white leghorn chickens were used to transcriptome analysis in chicken trachea immunized with infectious laryngotracheitis virus vaccine. In conclusion, chicken embryo origin (CEO) vaccine activation of the MHC-I and MHC-II pathways provides insight into the molecular mechanism of immune response in chickens, and holds potential for evaluation and design of new ILT vaccines in a manner adapted to the host immune response to the virus.

2014-04-08 | GSE46046 | GEO

Transcriptome analysis reveals an activation of MHC-I and MHC-II pathways in chicken trachea immunized with infectious laryngotracheitis virus vaccine

2014-04-08 | E-GEOD-46046 | biostudies-arrayexpress

Development of gene expression signatures for chicken LMH cells infected with infectious laryngotracheitis virus (ILTV)

Project description:To explore the molecular events in LMH cells upon infectious laryngotracheitis virus (ILTV) infection, transcriptional profiling of LMH cells infected with ILTV was compared with uninfected control cells. Gene expression in LMH cells with or without virus infection was measured at two day post infection. Four independent experiments were performed.

2015-10-24 | E-GEOD-70855 | biostudies-arrayexpress

Methylome Analysis in Chickens Immunized with Infectious Laryngotracheitis Vaccine

Project description:In this study we investigated the methylome of chickens immunized with Infectious laryngotracheitis (ILT) vaccine derived from chicken embryos. Methyl-CpG binding domain protein-enriched genome sequencing (MBD-Seq) method was employed in the detection of the 1,155 differentially methylated regions (DMRs) across the entire genome. After validation, we ascertained the genomic DMRs distribution and annotated them regarding genes, transcription start sites (TSS) and CpG islands. We found that global DNA methylation decreased in vaccinated birds, presenting 704 hypomethylated and 451 hypermethylated DMRs, respectively. Additionally, we performed an enrichment analysis detecting gene networks, in which cancer and RNA post-transcriptional modification appeared in the first place, followed by humoral immune response, immunological disease and inflammatory disease. The top four identified canonical pathways were EIF2 signaling, regulation of EIF4 and p70S6K signaling, axonal guidance signaling and mTOR signaling, providing new insight regarding the mechanisms of ILT etiology. Lastly, the association between DNA methylation and differentially expressed genes was examined, and detected negative correlation in seventeen of the eighteen genes. DNA methylation analysis employing MBD-Seq with 3 salt concentrations, in vaccinated and control group of chickens with 2 biological replications

2014-08-28 | E-GEOD-56984 | biostudies-arrayexpress

Methylome Analysis in Chickens Immunized with Infectious Laryngotracheitis Vaccine

2014-08-28 | GSE56984 | GEO

Infectious laryngotracheitis virus induces paracrine apoptosis in uninfected cells through repression of p53 signalling

Project description:We sequenced mRNA from LMH cells infected with ILTV, uninfected apoptotic cells and apoptotic cells cultured in conditioned medium.

2018-06-21 | GSE103371 | GEO

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