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Compatibility with Killer explains the Rise of RNAi-deficient Fungi

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Saccharomyces cerevisiae

PROVIDER: GSE31300 | GEO | 2011/08/10

SECONDARY ACCESSION(S): PRJNA146117

REPOSITORIES: GEO

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Compatibility with Killer explains the Rise of RNAi-deficient Fungi

Project description:This SuperSeries is composed of the following subset Series: GSE31288: The impact of RNAi on the Saccharomyces cerevisiae transcriptome GSE31290: Small RNAs in S. cerevisiae reconstituted with RNAi Refer to individual Series

2011-08-09 | E-GEOD-31300 | biostudies-arrayexpress

Compatibility with killer explains the rise of RNAi-deficient fungi.

Project description:The RNA interference (RNAi) pathway is found in most eukaryotic lineages but curiously is absent in others, including that of Saccharomyces cerevisiae. We show that reconstituting RNAi in S. cerevisiae causes loss of a beneficial double-stranded RNA virus known as killer virus. Incompatibility between RNAi and killer viruses extends to other fungal species in that RNAi is absent in all species known to possess double-stranded RNA killer viruses, whereas killer viruses are absent in closely related species that retained RNAi. Thus, the advantage imparted by acquiring and retaining killer viruses explains the persistence of RNAi-deficient species during fungal evolution.

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Compatibility with Killer explains the Rise of RNAi-deficient Fungi

Project description:Compatibility with Killer explains the Rise of RNAi-deficient Fungi

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