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Runx3 Regulates Interleukin-15-Dependent Natural Killer Cell Activation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Joseph Lotem

PROVIDER: E-GEOD-52625 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcription factor Runx3 regulates interleukin-15-dependent natural killer cell activation.

Levanon Ditsa D Negreanu Varda V Lotem Joseph J Bone Karen Rae KR Brenner Ori O Leshkowitz Dena D Groner Yoram Y

Molecular and cellular biology 20140113 6

Natural killer cells belong to the family of innate lymphoid cells comprising the frontline defense against infected and transformed cells. Development and activation of natural killer cells is highly dependent on interleukin-15 signaling. However, very little is known about the transcription program driving this process. The transcription factor Runx3 is highly expressed in natural killer cells, but its function in these cells is largely unknown. We show that loss of Runx3 impaired interleukin- ...[more]

PMID: 24421391

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