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Genome-wide mapping of histone methylation in human melanocytes and melanoma cell lines

ABSTRACT: Aberrant DNA methylation and histone modifications both contribute to carcinogenesis, but how these two epigenetic factors interact to impact gene expression remain unclear. To address this issue, we studied gene expression profiles, DNA methylation and two key histone modifications (H3K4me3 and H3K27me3), in two types of normal melanocytes (HEMn and HEMa) and two melanoma cell lines SK-MEL-28 and LOXIMVI. Using these data, we analyzed the relationship between epigenetic factors and gene expression status in both normal and melanoma cells, and the impact of epigenetic switches on gene expression during melanomagenesis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE33930 | GEO | 2013/12/01

SECONDARY ACCESSION(S): PRJNA148233

REPOSITORIES: GEO

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Genome-wide mapping of histone methylation in human melanocytes and melanoma cell lines

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