Genomics

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ATRX-mediated chromatin association of histone variant macroH2A1 regulates alpha globin gene expression


ABSTRACT: The histone variant macroH2A generally associates with transcriptionally inert chromatin, however the factors that regulate its chromatin incorporation remain elusive. Here, we identify the SWI/SNF helicase, ATRX, as a novel macroH2A interacting protein. Unlike its role in assisting H3.3 chromatin deposition, ATRX acts as a negative regulator of macroH2A’s chromatin association. In human erythroleukemic cells deficient for ATRX, ChIP-sequencing studies reveal that macroH2A accumulates at the HBA gene cluster on the subtelomere of chromosome 16, coinciding with the loss of α globin expression. Collectively, our results implicate deregulation of macroH2A’s distribution as a contributing factor to the α thalassemia phenotype of ATRX syndrome.

ORGANISM(S): Homo sapiens

PROVIDER: GSE35339 | GEO | 2012/03/08

SECONDARY ACCESSION(S): PRJNA152709

REPOSITORIES: GEO

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