Transcriptomics

Dataset Information

0

Expression data from mouse neonatal ovarian 3MC culture experiments


ABSTRACT: Mammalian females are born with a finite number of non-renewing primordial follicles, the majority of which remain in a quiescent state for many years. Due to their non-renewing nature, these resting oocytes are particularly vulnerable to xenobiotic insult, resulting in premature ovarian senescence and the formation of dysfunctional oocytes. In this study we characterised the mechanisms of ovotoxicity for the ovotoxic agent 3-methylcholanthrene (3MC), which targets immature follicles. Neonatal mouse ovaries (PND3-4) were cultured in the presence of 3MC (5 µM) for 96 hours to observe their effects on the ovarian transcriptome. This was done in the hopes of gaining a better understanding of the mechanisms underpinning xenobiotic induced pre-antral ovotoxicity.

ORGANISM(S): Mus musculus

PROVIDER: GSE35836 | GEO | 2012/02/16

SECONDARY ACCESSION(S): PRJNA151963

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2012-02-16 | E-GEOD-35836 | biostudies-arrayexpress
2011-05-13 | GSE29263 | GEO
2011-05-13 | E-GEOD-29263 | biostudies-arrayexpress
2010-08-21 | GSE23725 | GEO
2012-12-13 | GSE42889 | GEO
2012-12-13 | E-GEOD-42889 | biostudies-arrayexpress
2021-09-09 | PXD021338 | Pride
2008-06-11 | E-GEOD-11133 | biostudies-arrayexpress
2021-10-26 | GSE186504 | GEO
2013-02-04 | GSE34671 | GEO