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Colon tissue of Il10-/- mice monoassociated with Escherichia coli NC101 or NC101-delta-pks

ABSTRACT: We observed that deletion of polyketide synthase (pks) from E. coli NC101 reduces its ability to induce tumors in interleukin-10 knockout (Il10-/-) mice injected with azoxymethane (AOM), without altering histologic inflammation. The goal of this experiment is to assess inflammatory cytokine levels in colonic tissue of these mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE39095 | GEO | 2012/07/04

SECONDARY ACCESSION(S): PRJNA169937

REPOSITORIES: GEO

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Colon tissue of Il10-/- mice monoassociated with Escherichia coli NC101 or NC101-delta-pks

Project description:We observed that deletion of polyketide synthase (pks) from E. coli NC101 reduces its ability to induce tumors in interleukin-10 knockout (Il10-/-) mice injected with azoxymethane (AOM), without altering histologic inflammation. The goal of this experiment is to assess inflammatory cytokine levels in colonic tissue of these mice. 2 germ-free Il10-/- mice were assayed and used as controls. 3 E. coli NC101 and 3 E. coli NC101-delta-pks monoassociated mice were experimental samples.

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