Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Colon tissue of Il10-/- mice monoassociated with Escherichia coli NC101 or Escherichia faecalis OG1RF (PAMM-073 array)

ABSTRACT: We observed that interleukin-10 knockout (Il10-/-) mice injected with azoxymethane (AOM) and monoassociated with E. coli NC101, but not E. faecalis OG1RF, develop tumors. Histologic inflammation is not different in mice monoassociated with either bacterium. The goal of this experiment is to assess inflammatory cytokine levels in colonic tissue of these mice. 4 germ-free Il10-/- mice were assayed and used as controls. 4 E. coli and 4 E. faecalis monoassociated mice were experimental samples.

ORGANISM(S): Mus musculus

SUBMITTER: Janelle Arthur 

PROVIDER: E-GEOD-39094 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Inflammation alters host physiology to promote cancer, as seen in colitis-associated colorectal cancer (CRC). Here, we identify the intestinal microbiota as a target of inflammation that affects the progression of CRC. High-throughput sequencing revealed that inflammation modifies gut microbial composition in colitis-susceptible interleukin-10-deficient (Il10(-/-)) mice. Monocolonization with the commensal Escherichia coli NC101 promoted invasive carcinoma in azoxymethane (AOM)-treated Il10(-/-)  ...[more]

Similar Datasets

Transcriptomics Colon tissue of Il10-/- mice monoassociated with Escherichia coli NC101 or Escherichia faecalis OG1RF (PAMM-077 array)
2012-07-04 | E-GEOD-39092 | biostudies-arrayexpress
Transcriptomics Colon tissue of Il10-/- mice monoassociated with Escherichia coli NC101 or Escherichia faecalis OG1RF (PAMM-073 array)
2012-07-04 | GSE39094 | GEO
Transcriptomics Colon tissue of Il10-/- mice monoassociated with Escherichia coli NC101 or Escherichia faecalis OG1RF (PAMM-077 array)
2012-07-04 | GSE39092 | GEO
Transcriptomics Colon tissue of Il10-/- mice monoassociated with Escherichia coli NC101 or NC101-delta-pks
2012-07-04 | E-GEOD-39095 | biostudies-arrayexpress
Transcriptomics Colon tissue of Il10-/- mice monoassociated with Escherichia coli NC101 or NC101-delta-pks
2012-07-04 | GSE39095 | GEO
Transcriptomics Transcriptomes of Enterococcus faecalis OG1RF and OG1RF Δbph in planktonic culture
2022-03-12 | GSE198051 | GEO
Proteomics Proteomics of phage VPE25 treated Enterococcus faecalis OG1RF relative to untreated controls
2024-07-27 | PXD026873 | Pride
Transcriptomics Enterococcus faecalis OG1RF vs. Δrel mutants under control or mupirocin-treated conditions
2011-12-20 | GSE34561 | GEO
Transcriptomics Genome-wide Analysis of Enterococcus faecalis OG1RF Gene Expression During Infection
2013-12-15 | GSE22391 | GEO
Genomics Mus musculus
| PRJNA169931 | ENA