Site-specific silencing of regulatory elements as a mechanism of X-inactivation
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ABSTRACT: The inactive X chromosome’s (Xi) physical territory is microscopically devoid of transcriptional hallmarks and enriched in silencing-associated modifications. How these microscopic signatures relate to specific Xi sequence is unknown. This study reports the profiling of Xi gene expression and chromatin states at high-resolution via allele-specific sequencing in F1 hybrid mouse trophoblast stem cells (TSCs). Datasets provided include those generated from strand-specific RNA-Seq, ChIP-Seq, FAIRE-Seq, and DNase-Seq protocols. Included for each dataset are FASTQ files, BED alignments and WIG files with coordinates relative to UCSC genome build mm9, and _snp files that report the location of all SNP-overlapping reads.
ORGANISM(S): Mus musculus
PROVIDER: GSE39406 | GEO | 2012/11/21
SECONDARY ACCESSION(S): PRJNA170844
REPOSITORIES: GEO
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