Transcriptomics

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Genome-wide analysis of the SNAPc complex [Illumina array]


ABSTRACT: The small nuclear RNA (snRNA)-activating protein complex (SNAPc) is a basal transcription factor that mediates the transcriptional activation of snRNAs. Here, we describe the genome-wide occupancy of the SNAPC1_and SNAPC4 subunits of SNAPc. While the SNAPC4 occupancy was in accord with the role for SNAPc in snRNA transcription, SNAPC1_displayed a broader genomic profile mirroring that of RNA polymerase II at highly active protein-coding genes. Our functional analysis revealed a role for SNAPC1_in regulation of both basal and activator-induced transcription of protein-coding genes. These studies expand the role for SNAPC1_beyond its regulation of snRNA transcription.

ORGANISM(S): Homo sapiens

PROVIDER: GSE41528 | GEO | 2012/10/12

SECONDARY ACCESSION(S): PRJNA177368

REPOSITORIES: GEO

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