Annexin A2 Modulates Radiation-Sensitive Transcriptional Programming and Cell Fate
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ABSTRACT: Whole genome expression profiling in the presence and absence of annexin A2 [shRNA] identified fundamentally altered transcriptional programming that changes the radioresponsive transcriptome. Bioinformatics predicted that silencing AnxA2 may enhance cell death responses to stress in association with reduced activation of pro-survival signals such as nuclear factor kappa B. This prediction was validated by demonstrating a significant increase in sensitivity toward tumor necrosis factor alpha induced cell death in annexin A2 silenced cells, relative to vector controls, associated with reduced nuclear translocation of RelA (p65) following tumor necrosis factor alpha treatment.
ORGANISM(S): Mus musculus
PROVIDER: GSE42547 | GEO | 2012/11/28
SECONDARY ACCESSION(S): PRJNA182329
REPOSITORIES: GEO
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