Direct reprogramming of human fibroblasts to functional hepatocyte-like cells
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ABSTRACT: Plasticity of differentiated cells has been proved by nuclear transfer, induced pluripotent cells and transdifferentiation. Here we show that by transduction of 3 factors (FOXA3, HNF1A and HNF4A), human fetal fibroblasts can be converted to hepatocyte-like cells (hiHep cells), expressing hepatic marker genes, and acquiring many mature hepatocyte functions in vitro and in vivo.
ORGANISM(S): Homo sapiens
PROVIDER: GSE42643 | GEO | 2014/03/06
SECONDARY ACCESSION(S): PRJNA182503
REPOSITORIES: GEO
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