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Gene Expression Defines Natural Changes in Mammalian Lifespan

ABSTRACT: Mammals differ more than hundred fold in maximum lifespan, which can be altered in either direction during evolution, but the molecular basis for natural changes in longevity is not understood. Divergent evolution of mammals also led to extensive changes in gene expression within and between lineages. To understand the relationship between lifespan and variation in gene expression, we carried out RNA-seq-based gene expression analyses of liver, kidney and brain of 33 diverse species of mammals. Our analysis uncovered parallel evolution of gene expression and lifespan, as well as the associated life history traits, and identified the processes and pathways involved. These findings provide direct insights into how Nature reversibly adjusts lifespan and other traits during adaptive radiation of lineages.

ORGANISM(S): Meles meles Mesocricetus auratus Bos taurus Ursus americanus Chlorocebus aethiops Rattus norvegicus Mus musculus Canis lupus familiaris Erinaceus europaeus Tamias sibiricus Oryctolagus cuniculus Tadarida brasiliensis Meriones unguiculatus Felis catus Peromyscus leucopus Equus caballus Sus scrofa Cavia porcellus Suncus murinus Acomys cahirinus Petaurus breviceps Capra hircus Murina leucogaster

PROVIDER: GSE43013 | GEO | 2015/02/17

SECONDARY ACCESSION(S): PRJNA184055

REPOSITORIES: GEO

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Gene Expression Defines Natural Changes in Mammalian Lifespan

Project description:Mammals differ more than hundred fold in maximum lifespan, which can be altered in either direction during evolution, but the molecular basis for natural changes in longevity is not understood. Divergent evolution of mammals also led to extensive changes in gene expression within and between lineages. To understand the relationship between lifespan and variation in gene expression, we carried out RNA-seq-based gene expression analyses of liver, kidney and brain of 33 diverse species of mammals. Our analysis uncovered parallel evolution of gene expression and lifespan, as well as the associated life history traits, and identified the processes and pathways involved. These findings provide direct insights into how Nature reversibly adjusts lifespan and other traits during adaptive radiation of lineages. RNA-seq gene expression profiling in normal liver, kidney and brain of 33 mammalian species.

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